The airline is to take delivery of another Embraer 190 in the late summer, bringing the total fleet size to 14 aircraft.
It will be used for new year-round flights to Venice and to increase frequency to the key business destinations of Frankfurt from March and Glasgow from September.
The new route means even more choice for customers wanting to take holidays in Venice, the gateway to Northern Italy, when the flights launch in September and there will be one extra flight a day to Frankfurt and Glasgow.
The news comes as British Airways is about to start brand new services from the Docklands airport to Mahon in Menorca, Quimper in Britanny and Angers in the Loire Valley in France from May.
As the airline continues to grow its network, passengers now have more choices of leisure destinations when they fly from London City on one of the youngest aircraft fleets in the business. A total of 22 destinations in the UK, Europe and the USA will be served by British Airways from London City Airport.
Peter Simpson, managing director British Airways wholly owned subsidiary airline BA CityFlyer, said: "We are very excited about the arrival of our 14th aircraft which will add frequency to existing business destinations and has opened up new flying possibilities to popular leisure destinations. Our customers love the quick and easy service at London City, just 15 minutes from curbside to airside, making the most of their valuable time.
"We have some very competitive all inclusive fares to all our destinations, which include a generous free 23kg luggage allowance, free on-line check-in and seat selection 24 hours before departure and complimentary food and drink on board."